Submit Manuscript  

Article Details

Successful Control of a Co-Infection Caused by Candida albicans and Pseudomonas aeruginosa in Keratitis

[ Vol. 21 , Issue. 2 ]


Debarati Paul, Suman Saha, Neelam Singh, Jayansgu Sengupta and Santi M. Mandal*   Pages 290 - 294 ( 5 )


Introduction: Nowadays, the co-infection of different classes of pathogens is a major concern. The objective of this study was to develop a successful therapy for keratitis caused by the co-infection of Candida sp. with Pseudomonas sp, which is difficult to cure. The study is based on a 47 years old male farmer showing redness and watering in the right eye for 15-days.

Methods: The microbiological examination was performed to isolate the causative organisms, i.e. Pseudomonas aeruginosa and Candida albicans. They were cultured separately along with their co-culture and treated with ciprofloxacin and amphotericin B during the growing stage to predict a definite cure.

Results: Scanning electron microscope (SEM) results confirmed the inter-specific interaction between the two different types of microorganisms. Amphotericin-B and Ciprofloxacin showed the least MIC value for both organisms in co-culture.

Conclusion: Treatment with Amphotericin-B and 5% ciprofloxacin effectively hindered the growth of Pseudomonas aeruginosa and Candida albicans, the co-infection of which caused keratitis. This therapy may be successfully implied for such cases of co-infection in the future.


Amphotericin-B, Candida albicans, ciprofloxacin, co-infection, keratitis, Pseudomonas aeruginosa.


Amity Institute of Biotechnology, Amity University, Noida, Sector 125, 201313, Priyamvada Birla Aravind Eye Hospital, Kolkata, 700017, WB, Babasaheb Bhimrao ambedkar University, Department of Brain and Cognition Science, 226025Lucknow, Priyamvada Birla Aravind Eye Hospital, Kolkata, 700017, WB, Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur- 721302, Wes Bengal

Read Full-Text article