Submit Manuscript  

Article Details


Pulmonary Nocardiosis in Pemphigus Vulgaris Patients from Tehran, Iran

Author(s):

Hossein Ali Rahdar, Abass Bahador, Shahram Shahraki-Zahedani, Morteza Karami-Zarandi, Tahere Soori, Sirous Jafari and Mohammad Mehdi Feizabadi*   Pages 1 - 6 ( 6 )

Abstract:


Objective: Nocardiosis is an opportunistic infection in individuals who had organ transplants and in patients with immunosuppressive diseases, such as pemphigus vulgaris (PV), diabetes mellitus, and HIV. Nocardiosis rate has not been assessed in Iranian PV patients, and this was the first study to estimate nocardiosis rate in these patients.

In this study, 103 PV patients have been studied. BAL samples were obtained and direct smear was analyzed by PAS staining. Samples were cultured on antibiotic containing blood and chocolate agar media. DNA extraction and PCR were performed on positive cultures, and final identification was done by 16S rRNA gene sequencing. Drug susceptibility testing was done by micro-broth dilution method.

Results: Four positive cultures (3.88%) were found in the samples (n = 103). According to sequence analysis, 2 isolates were identified as N. cyriacigeorgica and 2 as N. otitidiscaviarum and N. cerradoensis. N. cerradoensis isolated from an invasive brain infection. Isolated bacteria were susceptible to majority of the tested antibiotics, except 1 isolate of N. cyriacigeorgica and isolate of N. cerradoensis. This was the first isolation of N. cerradoensis of human infection in Asia. PV patients are as susceptible to nocardiosis as other immunocompromised patients.

Keywords:

Nocardia Infection in patients with pemphigus Vulgaris in Tehran, Iran

Affiliation:

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Department of Medical Microbiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Department of Infectious Diseases, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Department of Infectious Diseases, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran



Read Full-Text article