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Evaluation of the Status of Salivary Antioxidants in Dental Caries


Seyedeh Sareh Hendi, Mohammad Taghi Goodarzi, Abbas Moghimbeigi and Fatemeh Ahmadi-Motamayel*   Pages 1 - 6 ( 6 )


Background and Aim: Dental caries is one of the most common, communicable and infectious disease worldwide. Oxidative stress may play a role in caries pathogenesis and salivary antioxidants may play a preventive role on dental caries. The aim of this study was to evaluate salivary superoxide dismutase, peroxidase, glutathione peroxidase, catalase and uric acid in dental caries.

Material and Method: 100 healthy students in two female and male (50) groups subdivided to caries active and caries free (25) groups. Un-stimulated whole saliva specimens were collected in the morning. Salivary superoxide dismutase, peroxidase, glutathione peroxidase, catalase and uric acid were measured by Spectrophotometric assay. Data were analyzed using Student’s t-test.

Results: The results showed that caries active group had higher peroxidase, uric acid, catalase, glutathione peroxidase and lower superoxide dismutase as compared to caries free group. Comparison between males and females, showed lower peroxidase, catalase, uric acid and higher glutathione peroxidase in female group.

Conclusion: Caries active group had changed salivary antioxidants levels. So salivary antioxidants may play an important role in caries prevention, formation and progression


Saliva, Enzymatic antioxidants, Molecular antioxidants, dental caries


Assistant professor of Endodontics, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Professor of biochemistry , Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Assistant professor, Professor of Biostatistic, School of Public Health, Hamadan University of Medical Science, Hamadan, Associate professor of Oral Medicine, Dental Implant Research Center and Dental Research Center, , Hamadan University of Medical Sciences, Hamadan

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