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Hepatitis a Seroprevalence Among Patients with Chronic Hepatitis B Infection: A Cross-Sectional Study in Iran During 2016-2017

Author(s):

Seyyed Ali Dehghan Manshadi, Neda Alijani, Mohammadreza Salehi, Omid Dadras, Seyyed Ahmad Seyed Alinaghi, Ailar Ahangari, Alireza Abdolahi, Hamidreza Davoudi and Ramazanali Alizade   Pages 1 - 3 ( 3 )

Abstract:


Introduction: The aim of this study was to determine the prevalence of exposure to hepatitis A by means of serologic markers in chronic hepatitis B patients, with the secondary aim of finding the best prevention method for hepatitis A infection in susceptible groups of our setting.

Methodology: During the period between 2016 and 2017, we recruited 403 hepatitis B patients aged more than 14 years and regularly attending the infectious diseases clinic at a referral university hospital, Tehran, Iran. A blood sample was collected from all the patients and tested for hepatitis A IgG. The data was analyzed by SPSS v.19.

Results: Although none of the patients had previously received hepatitis A vaccine, the results for serologic level of hepatitis A IgG, demonstrated positive results in 379 (94%) cases. The mean age of patients with negative and positive IgG was 29.17 and 42.46 years, respectively; the difference was statistically significant (P≤0.001). The majority of seronegative patients were young adults aged < 25 years and 25 to 35 years (P <0.001).

Discussion: Considering the high seroprevalence of hepatitis A in chronic hepatitis B patients in Iran, particularly in patients younger than 35 years old, the immunization for seronegative hepatitis B patients is strongly recommended.

Keywords:

Seroprevalence, chronic hepatitis B, hepatitis A IgG, Iran

Affiliation:

Department of Infectious Diseases and Tropical Medicine, Tehran University of Medical Sciences, Tehran, Department of Infectious Diseases and Tropical Medicine, Tehran University of Medical Sciences, Tehran, Department of Infectious Diseases and Tropical Medicine, Tehran University of Medical Sciences, Tehran, Department of Global Health and Socioepidemiology, Graduate School of Medicine, Kyoto University, Kyoto, Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Department of Infectious Diseases and Tropical Medicine, Tehran University of Medical Sciences, Tehran, Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Department of Pharmaceutical Care, Imam-Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Department of Infectious Diseases and Tropical Medicine, Tehran University of Medical Sciences, Tehran



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