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Systematic Review and Meta-analysis of Carbapenem Resistance of Acinetobacter baumannii in Iran

Author(s):

Pegah Shakib, Zeinab Babaie Choolandaimy, Faranak Rezaie, Mahmood Bahmani and Somayeh Delfani*   Pages 1 - 10 ( 10 )

Abstract:


Introduction: The prevalence of carbapenem resistance in Acinetobacter baumannii (A. baumannii) has been increased in worldwide. Thus therapeutic options are extremely limited. We performed a systematic review to evaluate of phenotypic and genotypic carbapenem resistance in A.baumannii reported in Iran.

Methods: We systematically searched Pub Med, Web of Science direct and Google scholar databases to identify studies addressing the carbapenem resistance of A. baumannii. From the first 71 papers. Selected papers were published between 2005 and November 2016 .Although sample collection year, between 2002 and 20116. To estimate the prevalence of the DerSimonian and Laird randomized models, 95% confidence interval was used. For heterogeneity check, I2 was used. The Egger test was used to check the propagation bias.

Results: Analysis of data exposed that there was an increase in resistance to carbapenems from 4.5% to 2005 year until 100% to 2016 year prevalence rate 65.4 (95% CI: 58.8 – 71.6).

Conclusion: According to result of this study, the rate of resistance to carbapenem in A.baumannii the increasing in Iran. Present of carbapenem resistant isolates are major concern because carbapenems are main drug against MDR isolates.

Keywords:

Carbapenem resistance, Acinetobacter baumannii, Phenotypic, Genotypic

Affiliation:

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad



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