Eltayib H Ahmed Abakur, Tarig MS Alnour*, Faisel Abuduhier, Fahad MA Albalawi and Khalid AS Alfifi Pages 1 - 4 ( 4 )
Purpose: Heteroresistance Mycobacterium tuberculosis (MTB) is diverse populations of drug-susceptible and resistant bacteria in a single clinical specimen from tuberculosis (TB) patients. Heteroresistance of MTB is considered a preliminary stage to full resistance. The present study aimed to determine the heteroresistance Mycobacterium tuberculosis in Tabuk province, north of the Kingdom of Saudi Arabia.Method: GenoType MTBDRplus assay was used to determine mutations associated with isoniazid and rifampicin resistances. Results: A total number of 46 confirmed M. tuberculosis positive sputum samples were scanned for the presence of heteroresistance. The present study revealed 3 (6.5%) heteroresistance to either rpoB gene alone 2 (4.4%) or both rpoB and inhA genes 1 (2.2%). Conclusion: The detection of hetroresistance mutations could guide the initiating of an appropriate regimen of treatment.
Heteroresistance, Mycobacterium tuberculosis, Drug resistance, rpoB mutation, inhA mutation
Faculty of Applied Medical Sciences – Department of Medical Laboratory Technology – University of Tabuk, Faculty of Medical Laboratory Sciences – Department of Microbiology and Immunology – Alzaiem Alazhari University, Academic affairs – University of Tabuk, King Fahad Specialist Hospital, Microbiology Technologist, King Fahad Specialist Hospital