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Emergence of Heteroresistance Mycobacterium Tuberculosis in Saudi Arabia

[ Vol. 20 , Issue. 4 ]

Author(s):

Eltayib H. Ahmed Abakur, Tarig M.S. Alnour*, Faisel Abuduhier, Fahad M.A. Albalawi and Khalid A.S. Alfifi   Pages 491 - 494 ( 4 )

Abstract:


Purpose: Heteroresistant Mycobacterium tuberculosis (MTB) is defined as a group of drug-susceptible and resistant bacteria in a single clinical specimen from tuberculosis (TB) patients. Heteroresistance of MTB is considered a preliminary stage to full resistance. The present study aimed to determine the heteroresistance in Mycobacterium tuberculosis in Tabuk province, in the north of the Kingdom of Saudi Arabia.

Method: GenoType MTBDRplus assay was used to determine mutations associated with isoniazid and rifampicin resistance.

Results: A total number of 46 confirmed M. tuberculosis positive sputum samples were scanned for heteroresistance. The present study revealed 3 (6.5%) heteroresistant mutations to either rpoB gene alone, 2 (4.4%) to rpoB and 1 (2.2%) to inhA genes.

Conclusion: The detection of heteroresistant mutations could guide the initiation of an appropriate regimen of treatment.

Keywords:

Heteroresistance, Mycobacterium tuberculosis, drug resistance, rpoB mutation, inhA mutation, Tuberculosis (TB).

Affiliation:

Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, 71491, Tabuk, Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, 71491, Tabuk, Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, 71491, Tabuk, University of Tabuk, 71491, Tabuk, King Fahad Specialist Hospital, Tabuk



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