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Emergence of Heteroresistance Mycobacterium tuberculosis in Saudi Arabia


Eltayib H Ahmed Abakur, Tarig MS Alnour*, Faisel Abuduhier, Fahad MA Albalawi and Khalid AS Alfifi   Pages 1 - 4 ( 4 )


Purpose: Heteroresistance Mycobacterium tuberculosis (MTB) is diverse populations of drug-susceptible and resistant bacteria in a single clinical specimen from tuberculosis (TB) patients. Heteroresistance of MTB is considered a preliminary stage to full resistance. The present study aimed to determine the heteroresistance Mycobacterium tuberculosis in Tabuk province, north of the Kingdom of Saudi Arabia.

Method: GenoType MTBDRplus assay was used to determine mutations associated with isoniazid and rifampicin resistances.

Results: A total number of 46 confirmed M. tuberculosis positive sputum samples were scanned for the presence of heteroresistance. The present study revealed 3 (6.5%) heteroresistance to either rpoB gene alone 2 (4.4%) or both rpoB and inhA genes 1 (2.2%).

Conclusion: The detection of hetroresistance mutations could guide the initiating of an appropriate regimen of treatment.


Heteroresistance, Mycobacterium tuberculosis, Drug resistance, rpoB mutation, inhA mutation


Faculty of Applied Medical Sciences – Department of Medical Laboratory Technology – University of Tabuk, Faculty of Medical Laboratory Sciences – Department of Microbiology and Immunology – Alzaiem Alazhari University, Academic affairs – University of Tabuk, King Fahad Specialist Hospital, Microbiology Technologist, King Fahad Specialist Hospital

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