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Hepatitis C Virus: Efficacy of New DAAs Regimens

[ Vol. 20 , Issue. 2 ]

Author(s):

Amal Ahmed Mohamed, Naglaa El-Toukhy Ramadan El-Toukhy, Ebada Mohamed Said, Hoda Mohamed Rabie Gabal, Hossameldin AbdelAziz, Wahid Doss, Hadeel El-Hanafi, Hala H. El Deeb, Seham Mahmoud, Mahmoud Elkadeem, Hassan Salama Shalby and Sherief Abd-Elsalam*   Pages 143 - 149 ( 7 )

Abstract:


Background: HCV treatment showed dramatical change due to the introduction of potent, strong, direct antiviral drugs. Before the appearance of Direct-acting antivirals, multiple therapeutic interventions were used for hepatitis C, but none of these interventions were effective on patient-centered outcomes. Direct-acting antivirals cause disruption of viral replication because they target specific nonstructural viral proteins.

Aim: To review the advantages of efficient HCV therapy and its long term drawbacks.

Methods: A search of the literature published in indexed databases (PubMed, Medline In-Process, and Embase) within the last 5 years was conducted. Any duplicated citations were excluded before first-pass screening. Citations (titles and abstracts) were screened for eligibility by a single reviewer. Full texts (including congress abstracts, posters and other congress communications) of citations deemed relevant during title and abstract screening were retrieved for second-pass review.

Results: Studies on the clinical effects of DAAs for hepatitis C show better tolerance, improved survival and fewer complications when compared to previous interferon therapy.

Conclusion: HCV treatment has improved dramatically. Since that time, there are multiple approved oral therapies all with high efficacy. The most important factor which should be considered during choosing appropriate therapy is to ensure that it covers the viral genotype of the infected patients.

Keywords:

Direct-acting antivirals, HCV therapy, HCV treatment, sofosbuvir, interferon, DAA.

Affiliation:

Biochemistry &Molecular Biology Department, National Hepatology& Tropical Medicine Research institute, Hepatology , gastroenterology and infectious diseases department, Benha Faculty of medicine, Benha University, Hepatology , gastroenterology and infectious diseases department, Benha Faculty of medicine, Benha University, Hepatology , gastroenterology and infectious diseases department, Benha Faculty of medicine, Benha University, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Department of Tropical Medicine, Faculty of Medicine, Cairo University, Clinical and Chemical Pathology,Kasr El-Einy hospitals. Cairo University , Clnical Pathology department, El Sahel teaching hospital, Tropical Medicine Department, El Sahel teaching hospital, Tropical Medicine Department, Tanta University, Internal Medicine Department, Faculty of Medicine, Misr Science and technology University, Tropical Medicine Department, Tanta University



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