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Epidemiology of Urinary Tract Infections in HIV Positive Patients at a Tertiary Care University Hospital in Central Europe (2011 - 2016)

[ Vol. 18 , Issue. 3 ]

Author(s):

Romana Klasinc, Armin Rieger, Elisabeth Presterl, Thomas Wrba and Magda Diab-Elschahawi*   Pages 199 - 206 ( 8 )

Abstract:


Objectives: There is limited published data concerning the recent epidemiology of urinary tract infections (UTI) in HIV-patients, thus we analysed independent risk factors for UTI in HIV positive individuals and antimicrobial resistance rates of E. coli to antimicrobial agents commonly used in UTI. To determine the prevalence of symptomatic urinary tract infections (UTI) in HIV-patients, we performed a retrospective case-control study.

Methods: We included 313 HIV-patients, 101 with UTI and 212 age and gendermatched controls, attending the HIV outpatient clinic at the Vienna University Hospital (VUH) over a period from January 2011 to September 2016. The patients’ specific data was gathered from the electronic database of the VUH. The statistical analysis was performed using SPSS Software Version 20.0.

Results: HIV infected individuals with CD4 count >200 cells/mm3 were less likely than HIV infected individuals with CD4 count <200 cells/mm3 to experience UTI (OR 0.811, 95% CI 0.712-0.923 vs. OR 2.555, 95% CI 1.553 - 4.205, respectively). The in vitro resistance rate of E. coli to antimicrobial agents was as follows: ciprofloxacin (41%), mecillinam (20.5%), trimethoprim (61%), ampicillin (67%), ampicillin/ clavulanic acid (23%), cefuroxime (17%), nitrofurantoin (2%), amikacin (0%) and gentamicin (9.5%).

Conclusion: Immunological status (CD4 count) is an important parameter for risk assessment of UTIs in HIV-patients. The increased resistance rate of E. coli to commonly used antimicrobial agents needs to be considered when it comes to the management of UTI, additionally, surveillance strategies should be implemented in HIV-patients.

Keywords:

HIV, Urinary tract infections, Epidemiology, Risk factors, Immunological status, Antimicrobial resistance.

Affiliation:

Department of Infection Control and Hospital Epidemiology, Medical University of Vienna, Vienna, Department of Dermatology, Division of Immundermatology and Infectious Diseases of the Skin, Medical University of Vienna, Vienna, Department of Infection Control and Hospital Epidemiology, Medical University of Vienna, Vienna, IT4Science, IT-Systems & Communications, Medical University of Vienna, Vienna, Department of Infection Control and Hospital Epidemiology, Medical University of Vienna, Vienna

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