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Evaluation of Salivary Uric Acid and pH in Human Immunodeficiency Virus Infected Patients: A Historical Cohort Study

[ Vol. 18 , Issue. 1 ]


Fatemeh Ahmadi-Motamayel*, Samaneh Vaziri Amjad, Mohammad Taghi Goodarzi and Jalal Poorolajal   Pages 35 - 40 ( 6 )


Objective: Antioxidants protect the body against cellular damage. Saliva has immunological, enzymatic and antioxidant defense systems. Uric acid is the main and predominant salivary antioxidant. The aim of this study was to evaluate salivary uric acid levels and pH in HIV-infected patients in the west of Iran.

Methods: HIV-infected patients were selected from behavioral advisory centers of Hamadan and Kermanshah Provinces, west of Iran. Saliva was collected between 8 and10 in the morning. Five mL of whole unstimulated saliva was collected in 5 minutes by spitting into sterilized Falcon tubes based on Navazesh method; pH was measured with a pH meter and uric acid was assessed with spectrophotometric method. Data were analyzed with STATA 12.

Results: Salivary pH in the HIV-positive group was lower (6.99±0.46) than the healthy controls (7.14±1.03) but the difference was not statistically significant (P=380). Uric acid concentrations in HIV-infected patients (2.94±2.14) were significantly lower in comparison to the healthy controls (5.21±2.30). The results showed a statistically significant decrease in the case group (P=0.001). Mean age and DMFT index of the case group were higher than the control group.

Conclusion: Uric acid, the main antioxidant of saliva, was significantly lower in HIVinfected individuals; pH also was lower in these patients. HIV can alter salivary antioxidant status, which can influence patients' oral health status. Diet with antioxidant properties might be helpful in these patients. More research is necessary to discover true antioxidant and salivary changes and their relation with HIV consequences in future.


Uric acid, pH, saliva, HIV, antioxidant, salivary changes.


Research Center for Molecular Medicine and Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Department of Oral Medicine, Dental School, Hamadan University of Medical Sciences, Hamadan, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Associate professor, Research Center for Health Sciences and Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan

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