Submit Manuscript  

Article Details


In silico Analysis of Toxins of Staphylococcus aureus for Validating Putative Drug Targets

[ Vol. 17 , Issue. 2 ]

Author(s):

Ramadevi Mohana and Subhashree Venugopal*   Pages 130 - 142 ( 13 )

Abstract:


Toxins are one among the numerous virulence factors produced by the bacteria. These are powerful poisonous substances enabling the bacteria to encounter the defense mechanism of human body. The pathogenic system of Staphylococcus aureus is evolved with various exotoxins that cause detrimental effects on human immune system. Four toxins namely enterotoxin A, exfoliative toxin A, TSST-1 and γ-hemolysin were downloaded from Uniprot database and were analyzed to understand the nature of the toxins and for drug target validation. The results inferred that the toxins were found to interact with many protein partners and no homologous sequences for human proteome were found, and based on similarity search in Drugbank, the targets were identified as novel drug targets.

Keywords:

Staphylococcus aureus toxins, in silico analysis, drug target validation, BLAST, interactome analysis.

Affiliation:

Department of Integrative Biology, VIT University, Vellore-632014, Tamil Nadu, Department of Integrative Biology, VIT University, Vellore-632014, Tamil Nadu

Graphical Abstract:



Read Full-Text article