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Use of Intra-Articular Amphotericin B in the Treatment of Candida parasilosis and albicans in Prosthetic Joint Infections (PJI): A Novel Approach to this Difficult Problem

[ Vol. 17 , Issue. 1 ]


Leigh G. Cooper, Jacob Heydemann, Gregory Misenhimer and Suresh Antony   Pages 36 - 42 ( 7 )


Background: Use of intra-articular antibiotics for the treatment of arthroplasty infections has gained some interest over the last few years.

Objective: Some data exists on its use with bacterial arthroplasty infections.

Method: We used intra-articular amphotericin B in an attempt to cure these joint infections and perform a one stage revision.

Results: Two patients were treated with intra-articular amphotericin B for 6 weeks followed by suppressive fluconazole for 4 months. Intra-articular joint fluid was cultured during this process for re-growth of fungus.

Conclusion: Both patients were treated successfully with the method with follow up showing no evidence of recurrence. IA administration of amphotericin B may be an alternative treatment in these patients.


Intra-articular, amphotericin B, prosthetic joint infection, candida, treatment failure, Hickman catheter.


New Mexico State University, El Paso Texas, Providence Medical Center, El Paso, Texas, Providence Medical Center, El Paso, Texas, 1205 N. Oregon El Paso, TX 79902, Texas

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