Article Details


Use of Intra-Articular Amphotericin B in the Treatment of Candida parasilosis and albicans in Prosthetic Joint Infections (PJI): A Novel Approach to this Difficult Problem

[ Vol. 17 , Issue. 1 ]

Author(s):

Leigh G. Cooper, Jacob Heydemann, Gregory Misenhimer and Suresh Antony   Pages 36 - 42 ( 7 )

Abstract:


Background: Use of intra-articular antibiotics for the treatment of arthroplasty infections has gained some interest over the last few years.

Objective: Some data exists on its use with bacterial arthroplasty infections.

Method: We used intra-articular amphotericin B in an attempt to cure these joint infections and perform a one stage revision.

Results: Two patients were treated with intra-articular amphotericin B for 6 weeks followed by suppressive fluconazole for 4 months. Intra-articular joint fluid was cultured during this process for re-growth of fungus.

Conclusion: Both patients were treated successfully with the method with follow up showing no evidence of recurrence. IA administration of amphotericin B may be an alternative treatment in these patients.

Keywords:

Intra-articular, amphotericin B, prosthetic joint infection, candida, treatment failure, Hickman catheter.

Affiliation:

New Mexico State University, El Paso Texas, Providence Medical Center, El Paso, Texas, Providence Medical Center, El Paso, Texas, 1205 N. Oregon El Paso, TX 79902, Texas

Graphical Abstract:



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