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ESBL E coli and P. aeruginosa Resistance to Ceftolozane-Tazobactam in a Patient with a Liver Abscess. The Search for an Omnipotent Antibiotic Goes On!

[ Vol. 18 , Issue. 1 ]

Author(s):

Mohamed Teleb, Enrique Soto-Ruiz, Delfina C. Dominguez and Suresh Antony*   Pages 81 - 85 ( 5 )

Abstract:


Multi drug resistant (MDR) Pseudomonas aeruginosa and Extended- Spectrum-lactamase (ESBL) Enterobacteriaceae are becoming an increasing difficult clinical problem. Immediate resistance to some of the new antimicrobials such as ceftolozane/tazobactam is unusual and is due to a variety of mechanisms such as hyper-production of inactivating enzymes and gene mutation. In addition, previous antimicrobial administration is a well-recognized risk factor to develop resistance. We present a patient with a liver abscess where the organism was resistant to ceftolozane/tazobactam resulting in a poor clinical outcome.

Keywords:

Ceftolozane/Tazobactam, ESBL, gram negative bacteria, mutation, pseudomonas, resistance.

Affiliation:

Section of Infectious Diseases, Department of Medicine, Texas Tech University, Texas 79902, Section of Infectious Diseases, Department of Medicine, Texas Tech University, Texas 79902, Department of Clinical Laboratory Sciencem, The University of Texas at El Paso, Lubbock, TX, Section of Infectious Diseases, Department of Medicine, Texas Tech University, Texas 79902

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